More than 80 Americans die every day from prescription opioid drug overdoses, and more than 3,900 people initiate the non-medical use of prescription opioids. Opioids are the most effective analgesics, however their addictive properties and serious adverse side effects cause major medical, societal, and economic problems - a cost estimated to exceed more than $55 billion each year.  Unfortunately there are very few alternatives.  Mirata Pharmaceuticals is developing new options for patients and physicians that provide the powerful pain relieving benefits of opioids, but without the significant side effects.